Physiologic Insulin Resensitization as a Treatment Modality ... - PubMed

pubmed.ncbi.nlm.nih.gov/35163806/
Insulin resistance leads to increasing insulin secretion, leading to beta-cell exhaustion or burnout. This triggers a cascade leading to islet cell destruction and the long-term complications of type 2 diabetes. ... nephropathy, and retinopathy, and that it lowers HbA1c. In conclusion, physiologic insulin resensitization has a persuasive ...

Physiological Insulin Resistance - Ketopia

ketopia.com/physiological-insulin-resistance/
The explanation I've read is that after going low carb, your muscle tissue becomes insulin resistant in order to preserve serum glucose availability for the brain. If your muscle tissue did not do this, reduced availability of glucose in the serum could (theoretically) put you in dire straights if your brain can't meet minimal demand for glucose.

Pathophysiology of insulin resistance - PubMed

pubmed.ncbi.nlm.nih.gov/17161338/
Insulin resistance in skeletal muscle manifests itself primarily as a reduction in insulin-stimulated glycogen synthesis due to reduced glucose transport. Ectopic lipid accumulation plays an important role in inducing insulin resistance.

What Is Physiological Insulin Resistance | DiabetesTalk.Net

diabetestalk.net/ketosis/what-is-physiological-insulin-resistance
It is a possible phenomenon called Physiological Insulin Resistance. The High Blood Glucose Dilemma on Low Carb (LC) Diets If you are on a ketogenic or very low carb (VLC) diet (e.g. with 50-100gr carb/day and/or eating ketone producing MCT oils such as coconut oil), you m Low insulin levels activate hormone sensitive lipase.

the physiological insulin resistance straw man argument

optimisingnutrition.com/physiological-insulin-resistance/
One of the criticisms that is levelled at low carbohydrate diets is that it causes what is called 'physiological insulin resistance '. This can mean that a person who is restricting carbohydrates may end up with higher fasting blood sugars and may have higher blood sugars after a higher carbohydrate meal.

Insulin Resistance: What It Is, Causes, Symptoms & Treatment

my.clevelandclinic.org/health/diseases/22206-insulin-resistance
Insulin resistance, also known as impaired insulin sensitivity, happens when cells in your muscles, fat and liver don't respond as they should to insulin, a hormone your pancreas makes that's essential for life and regulating blood glucose (sugar) levels. Insulin resistance can be temporary or chronic and is treatable in some cases.

Insulin Resistance as a Physiological Defense Against Metabolic Stress ...

diabetesjournals.org/diabetes/article/64/3/673/40358/Insulin-Resistance-as-a-Physiological-Defense
For example, in response to short-term overfeeding, skeletal and cardiac muscle become transiently insulin resistant ( 6, 7 ), a physiological adaptation that favors the diversion of excess nutrients to adipose tissue for storage.

Physiologic Insulin Resistance. It's A Good Thing!

community.myfitnesspal.com/en/discussion/478131/physiologic-insulin-resistance-its-a-good-thing
Pathological insulin resistance is a bad thing. Physiological resistance is a good thing. I think it's better to describe it as the insulin receptors on the cells that don't require glucose retract the since glucose needs to be preserved and the cells prefer to take up fat for fuel. They aren't resistant. They're just "turned off".

Physiological Vs Pathological Insulin Resistance - DiabetesTalk.Net

diabetestalk.net/ketosis/physiological-vs-pathological-insulin-resistance
Physiological insulin resistance is insulin resistance that is considered beneficial, as opposed to pathological insulin resistance, which is considered harmful. The idea of physiological insulin resistance is that is occurs on low-carb diets and serves to conserve carbohydrates, which would be scarce.

Low Carbing and Physiological Insulin Resistance

www.diabetes.co.uk/forum/threads/low-carbing-and-physiological-insulin-resistance.114504/
Physiological insulin resistance on a low carb diet isn't an issue unless you stop low carbing. Even then, about a week of a normal level of carb intake will reverse the physiological insulin resistance. I don't think everyone that low carbs gets physiological insulin resistance - I don't seem to have it. AndBreathe Master Retired Moderator

Mechanisms of Insulin Action and Insulin Resistance | Physiological Reviews

journals.physiology.org/doi/full/10.1152/physrev.00063.2017
In the 1970s and early 1980s, when INSR was the only known molecular effector of insulin action, several groups used insulin dose-response curves and 125 I-insulin binding studies to relate surface INSR content to physiological insulin action and resistance (26, 272, 378, 417, 420, 595, 787).

Insulin and Insulin Resistance — The Ultimate Guide - Healthline

www.healthline.com/nutrition/insulin-and-insulin-resistance
Insulin resistance, in which your cells stop responding to insulin, is incredibly common. In fact, over 32.2% of the U.S. population may have this condition ( 1 ). Depending on the diagnostic...

Should "physiological" insulin resistance be a concern?

www.reddit.com/r/ketoscience/comments/3dgobl/should_physiological_insulin_resistance_be_a/
If you have physiological insulin resistance, you are literally at the opposite end of the risk spectrum to a diabetic: You will have an extremely low HbA1c value. Your liver and kidneys will be very sensitive to the effect of insulin, even though muscle tissue isn't. You will almost never suffer hypoglycemic events.

Physiological Insulin Resistance - Resources - Ketogenic Forums

www.ketogenicforums.com/t/physiological-insulin-resistance/11168
Physiologic Insulin Resistance seems to be the body's response to carbohydrates (and excess protein to a 50% lesser degree) while insulin is LOW, but I seen nothing like a fasting insulin test to say that you're not experiencing regular insulin resistance (IR) which would mean that fasting insulin is above 13 uIU/mL.

The Two Types of Insulin Resistance - HLTH Code

gethlth.com/the-two-types-of-insulin-resistance/
Any claim of physiological insulin resistance in the context of a low-carb or ketogenic diet is simply incorrect. The only two instances of physiological insulin resistance are puberty and pregnancy, and in both instances, insulin is elevated. If there's no elevation in insulin, then the body is not experiencing insulin resistance. References

Development of a physiological insulin resistance model in ... - Science

www.science.org/doi/10.1126/sciadv.abn7298
Adipose tissue is central to metabolic health and disease ().The dysregulation of adipocyte function and loss of insulin sensitivity often observed in obesity is one of the key risk factors for the development of type II diabetes mellitus (T2D) ().However, in vitro adipocyte culture models poorly mimic the functional capabilities of in vivo adipose tissue for the study of insulin resistance.

Physiological Insulin Resistance? — MyFitnessPal.com

community.myfitnesspal.com/en/discussion/10356486/physiological-insulin-resistance
Physiological Insulin Resistance? nvmomketo Posts: 12,020 Member. March 2016 in Social Groups. I came to a LCHF diet, and then ketosis, to treat my emerging prediabetic blood glucose. I appeared to be early in insulin resistance and wanted to nip it in the bud. My fasting blood glucose was often between a 5.6 and 6.1 while eating a reasonable ...

PDF Physiologic Insulin Resensitization as a Treatment Modality for Insulin ...

restormetabolix.com/wp-content/uploads/2022/02/Greenway-Physiologic-Insulin-Resensitization-as-a-Treatment-Modality-for-Insulin-Resistance-Pathophysiology_02.08.22.pdf
This article has two purposes: (1) To explore insulin resistance pathophysiology and (2) to review literature for clinical outcomes and molecular mechanisms that support the use of physiologic insulin resensitization as an effective treatment modality to address insulin resistance, of which diabetes and its complications are the most common ...

Insulin Resistance: From Mechanisms to Therapeutic Strategies

www.ncbi.nlm.nih.gov/pmc/articles/PMC8831809/
Insulin resistance is defined physiologically as a state of reduced responsiveness in insulin-targeting tissues to high physiological insulin levels and is considered the pathogenic driver of many modern diseases, including metabolic syndrome, nonalcoholic fatty liver disease (NAFLD), atherosclerosis, and T2DM [ 1 ].

Series Introduction: The molecular and physiological basis of insulin ...

www.ncbi.nlm.nih.gov/pmc/articles/PMC314314/
Insulin resistance, which is defined as a state of reduced responsiveness to normal circulating concentrations of insulin, is now recognized as a characteristic trait of type 2 diabetes and contributes to abnormalities in all of these tissues.

Insulin Resistance | ADA - American Diabetes Association

diabetes.org/healthy-living/medication-treatments/insulin-resistance
People with insulin resistance, also known as impaired insulin sensitivity, have built up a tolerance to insulin, making the hormone less effective. As a result, more insulin is needed to persuade fat and muscle cells to take up glucose and the liver to continue to store it. Just why a person fails to respond properly to insulin is still a mystery.

Pathophysiology of insulin resistance in human disease | Physiological ...

journals.physiology.org/doi/abs/10.1152/physrev.1995.75.3.473
Evidence is presented that non-insulin-dependent diabetes mellitus (NIDDM) results from a failure on the part of pancreatic beta-cells to compensate adequately for the defect in insulin action in insulin-resistant individuals. In addition, a coherent formulation of the physiological changes that lead from the defect in cellular insulin action ...

Physiological Insulin Resistance = Low Carbohydrate Diet Induced ...

www.freetheanimal.com/2014/10/physiological-resistance-carbohydrate.html
Well, the first thing is that LC eating rapidly induces insulin resistance. This is a completely and utterly normal physiological response to carbohydrate restriction. Carbohydrate restriction drops insulin levels. Low insulin levels activate hormone sensitive lipase. Fatty tissue breaks down and releases non esterified fatty acids.

Does Keto Cause Insulin Resistance? The TRUTH! - Siim Land Blog

siimland.com/does-keto-cause-insulin-resistance-the-truth/
Physiological Insulin Resistance. It's been shown that after prolonged exposure, fatty acids will eventually inhibit glucose-induced insulin secretion.. Insulin resistance caused by fasting or the ketogenic diet is a temporary adaptation to preserving glucose for certain vital organs like the brain by blocking the uptake of glucose by muscles that would steal the glucose from the brain.

Insulin resistance - Wikipedia

en.wikipedia.org/wiki/Insulin_resistance
Insulin resistance (IR) is a pathological condition in which cells fail to respond normally to the hormone insulin. ... Its physiological role is to regulate hunger by alerting the body when it is full. Studies show that lack of leptin causes severe obesity and is strongly linked with insulin resistance.

Brain insulin resistance and cognitive function: influence of exercise ...

journals.physiology.org/doi/10.1152/japplphysiol.00375.2022
Exercise has systemic health benefits in people, in part, through improving whole-body insulin sensitivity. The brain is an insulin sensitive organ that is often underdiscussed relative to skeletal muscle, liver, and adipose tissue. While brain insulin action may have only subtle impacts on peripheral regulation of systemic glucose homeostasis, it is important for weight regulation as well as ...

Keto Protein Powder Sample Packs | Zero Carb | KetoGenics

www.ketoshop.com/blogs/news/ketogenic-diet-and-physiological-insulin-resistance-low-carb-diet-and-dawn-phenomenon
Physiological Insulin Resistance is a benign state that is not making your diabetic insulin resistance worse. A ketogenic dieter becomes adapted to sparing glucose for use by those cells which absolutely require it. Some brain cells, red blood cells and testes require glucose because they do not have mitochondria.

Does Long Term Ketosis Cause Insulin Resistance? - DocMuscles

www.docmuscles.com/does-long-term-ketosis-cause-insulin-resistance/
This fascinating glucose sparing phenomenon, has been interpreted by some as "worsening insulin resistance." Not to worry, glucose sparing is rapidly reversible and transitory within 1-3 days of increasing carbohydrate intake above 100-150 grams per day ( 1 ).
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